Two of the patches 10160615 and 12400751 are able to be applied in Online Mode. Its too bad 2 other patches can't be.. Regardless its nice to see that some patches are now able to be applied while the system is up.
For more information on Online Mode (Hot Patching) take a look at Metalink note:
|RDBMS Online Patching Aka Hot Patching [ID 761111.1]|